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Efficient Glycemic Control for the Management of Diabetes Complications : Intervention with Novel Point of Care Device for Community Healthcare

Primary Information

Domain

Healthcare

Project No.

4550

Sanction and Project Initiation

Sanction No: 111

Sanction Date: 01/04/2017

Project Initiation date: 15/04/2017

Project Duration: 24

Partner Ministry/Agency/Industry

Ministry of Health and Family Welfare

 

Role of partner: Provide support for the efficient execution of the project

 

Support from partner: Rs 16320000

Principal Investigator

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NAVAKANTA BHAT
Indian Institute of Science, Bangalore

Host Institute

Co-PIs

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P. BALARAM
Indian Institute of Science, Bangalore

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P. R. KRISHNASWAMY
Indian Institute of Science, Bangalore

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VINAY KUMAR
PathShodh Healthcare

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S S SRIKANTA
Samatvam Diabetes Centre

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Sujay Ramprasad
Anand Diagnostics Laboratory

 

Scope and Objectives

Scale up and Field deployment of Multi-analyte device for Diabetes management Demonstrate improved Diabetes outcome in cohort group within 2 years Demonstrate efficacy of Glycated Albumin as short term Glycemic Index and for patients with CKD and other complications Correlation of CKD instances and progression with HbA1c versus Glycated Albumin

Deliverables

Field deployment Multi-analyte PoCT devices - first such device for HbA1c and Glycated Albumin Comparison of HbA1c and Glycated Albumin, in the context of Diabetes complications Nutrition index through Hb and Albumin measurement Better diabetes management outcome (HbA1c<7) Healthcare sector, in particular rural healthcare delivery will be greatly benefited.

 

Scientific Output

Successfully scaled up and field deployed the hand held "Lab on Palm" device for point of care diagnosis of Diabetes and complications. Ease of use of handheld device was demonstrated through the use by the minimally trained health workers. Very detailed characterization of glycaton sites in Albumin through in-vitro and in-vivo studies

 

Results and outcome till date

Clear outcome in terms of efficient healthcare delivery by the blood tests performed through finger prick for assessing the disease condition. The features of Lab on Palm device have enabled remote diagnostics for Telemedicine applications.

 

Societal benefit and impact anticipated

This technology intervention can potentially bridge the healthcare divide

Next steps

Need to follow up the subjects/patients recruited under this study for the next one year. Need to correlate glycated albumin marker with the diabetic nephropathy related chronic kidney disease.

Publications and reports

Vinay Kumar, Navakanta Bhat et al; Application of a Nanotechnology-based, Point-of-Care Diagnostic Device in Diabetic Kidney Disease, Kidney International Reports, 2 June 2018 https://doi.org/10.1016/j.ekir.2018.05.008

Scholars and Project Staff

Pallavi Dasgupta (PhD scholar)
Madhumati Vaishnav (PhD scholar)
Namita (Project staff , Postdoctoral fellow)
Kanad (Project staff)
Amulya (Project staff)

Challenges faced

Lack of funds to transfer to the partners (Samatvam Diabetes centre and Anand Diagnostics Lab) since we are yet to receive Rs 1,43,66,000 from partner ministry (Ministry of Health)

Financial Information

  • Total sanction: Rs. 3,26,40,000

  • Amount received: Rs. 1,82,74,000

  • Amount utilised for Equipment: Rs. 0

  • Amount utilised for Manpower: Rs. 15,29,242

  • Amount utilised for Consumables: Rs. 20,25,554

  • Amount utilised for Contingency: Rs. 4,11,290

  • Amount utilised for Travel: Rs. 24,118

  • Amount utilised for Other Expenses: 1,17,60,000

  • Amount utilised for Overheads: Rs. 28,20,000

Equipment and facilities

 

Not Applicable

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