Efficient Glycemic Control for the Management of Diabetes Complications : Intervention with Novel Point of Care Device for Community Healthcare
Primary Information
Domain
Healthcare
Project No.
4550
Sanction and Project Initiation
Sanction No: 111
Sanction Date: 01/04/2017
Project Initiation date: 15/04/2017
Project Duration: 24
Partner Ministry/Agency/Industry
Ministry of Health and Family Welfare
Role of partner: Provide support for the efficient execution of the project
Support from partner: Rs 16320000
Principal Investigator
NAVAKANTA BHAT
Indian Institute of Science, Bangalore
Host Institute
Co-PIs
P. BALARAM
Indian Institute of Science, Bangalore
P. R. KRISHNASWAMY
Indian Institute of Science, Bangalore
VINAY KUMAR
PathShodh Healthcare
S S SRIKANTA
Samatvam Diabetes Centre
Sujay Ramprasad
Anand Diagnostics Laboratory
Scope and Objectives
Scale up and Field deployment of Multi-analyte device for Diabetes management Demonstrate improved Diabetes outcome in cohort group within 2 years Demonstrate efficacy of Glycated Albumin as short term Glycemic Index and for patients with CKD and other complications Correlation of CKD instances and progression with HbA1c versus Glycated Albumin
Deliverables
Field deployment Multi-analyte PoCT devices - first such device for HbA1c and Glycated Albumin Comparison of HbA1c and Glycated Albumin, in the context of Diabetes complications Nutrition index through Hb and Albumin measurement Better diabetes management outcome (HbA1c<7) Healthcare sector, in particular rural healthcare delivery will be greatly benefited.
Scientific Output
Successfully scaled up and field deployed the hand held "Lab on Palm" device for point of care diagnosis of Diabetes and complications. Ease of use of handheld device was demonstrated through the use by the minimally trained health workers. Very detailed characterization of glycaton sites in Albumin through in-vitro and in-vivo studies
Results and outcome till date
Clear outcome in terms of efficient healthcare delivery by the blood tests performed through finger prick for assessing the disease condition. The features of Lab on Palm device have enabled remote diagnostics for Telemedicine applications.
Societal benefit and impact anticipated
This technology intervention can potentially bridge the healthcare divide
Next steps
Need to follow up the subjects/patients recruited under this study for the next one year. Need to correlate glycated albumin marker with the diabetic nephropathy related chronic kidney disease.
Publications and reports
Vinay Kumar, Navakanta Bhat et al; Application of a Nanotechnology-based, Point-of-Care Diagnostic Device in Diabetic Kidney Disease, Kidney International Reports, 2 June 2018 https://doi.org/10.1016/j.ekir.2018.05.008
Scholars and Project Staff
Pallavi Dasgupta (PhD scholar)
Madhumati Vaishnav (PhD scholar)
Namita (Project staff , Postdoctoral fellow)
Kanad (Project staff)
Amulya (Project staff)
Challenges faced
Lack of funds to transfer to the partners (Samatvam Diabetes centre and Anand Diagnostics Lab) since we are yet to receive Rs 1,43,66,000 from partner ministry (Ministry of Health)
Financial Information
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Total sanction: Rs. 3,26,40,000
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Amount received: Rs. 1,82,74,000
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Amount utilised for Equipment: Rs. 0
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Amount utilised for Manpower: Rs. 15,29,242
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Amount utilised for Consumables: Rs. 20,25,554
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Amount utilised for Contingency: Rs. 4,11,290
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Amount utilised for Travel: Rs. 24,118
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Amount utilised for Other Expenses: 1,17,60,000
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Amount utilised for Overheads: Rs. 28,20,000
Equipment and facilities
Not Applicable