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Development of Advanced Holter Monitor with extended recording and episode detection

Primary Information



Project No.


Sanction and Project Initiation

Sanction No: F. No.: 3-18/2015-TS-TS.I

Sanction Date: 29/11/2016

Project Initiation date:01/04/2017

Project Duration: 36

Partner Ministry/Agency/Industry

Indian Council of Medical Research


Role of partner:


Support from partner:Partner Ministry arranged workshop at ICMR HQ., New Delhi where technology needs were identified. It helped in connecting to medical domain experts associated with the project to support the validation exercise. It also provided its 1st year's grant on October 05, 2017.

Principal Investigator

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Dr. Goutam Saha
Indian Institute of Technology Kharagpur

Host Institute


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Dr. Samit Ari
National Institute of Technology, Rourkella

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Dr. Nitish Naik

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Dr. Harikrishnan Sivadasan Pillai
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

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Dr. Anirban Mukherjee
Indian Institute of Technology Kharagpur


Scope and Objectives

Cardiac disease is one of the top causes of mortality worldwide, and condition such as sudden heart attack make the matter worse. The only way to mitigate this problem is regular check-up of heart condition. Manifestation of certain kind of heart abnormalities requires tracking of electrical activities associated with pumping of heart for longer duration. This can be done by a portable device worn by a subject for a certain period (24 hour or more). Extended monitoring of cardiac rhythm is currently available either as implantable devices or as external monitoring devices used under special care. These devices either display rhythms that have been pre-defined by the user or are activated by patient on the onset of symptoms. This leads to loss of valuable data on many important ECG variables such as ST segment, cumulative atrial and ventricular arrhythmia burden, heart rate variability, etc. and thus many important episodes tend to go undetected. Proposed is development of an advanced Holter Monitor which will overcome these limitations. Attempts will also be made to make it function like a remote cardiac monitor by wirelessly transmitting its data for its use in telemetry. The aim is to couple a wearable external device to a smart phone which can serve as a computing and display unit for episodes of interest or serve as a vehicle to connect to a server that can take higher computational load.


Projected outcome is two-fold. In one, a mobile phone based signal processing application will be developed that can process long duration electrocardiogram data. The signal processing engine will generate important physiological parameters for diagnostic use in an easy to read format. The algorithms will be benchmarked against the best in this field. In the other, attempt will be made to develop a customizable data acquisition hardware unit. This would be able to store long duration electrocardiogram data in a suitable format for its use in subsequent signal processing.


Scientific Output

We do not want to put the intermediate findings in the public domain. It will be put in due course after securing the IP / peer review. The findings were put before the expert reviewers in the last review meeting.


Results and outcome till date

Novel algorithm that identifies certain important physiological parameters have been developed and tested using longer duration electrocardiogram data from an internationally recognized database. A mobile phone app is developed that has already implemented few of the basic signal processing algorithms at its backend and its outcome is displayed in the screen. In the hardware development work, a primary study on wireless transfer of data and its display on mobile phone in raw format as well as a waveform is completed.


Societal benefit and impact anticipated

Among the top leading causes of death in the world, cardiovascular disease accounts for 17.5 million death per year, which approximates 31% of deaths in total. Arrhythmic death is a major contributor to death in patients with existing heart disease. There is a significant clinical need for assessment of arrhythmic burden in patients with ischemic heart disease. Currently available devices reveal limited data (either patient activated or operator defined ECG recordings) and are expensive. There lies a need to develop device for extended monitoring of cardiac rhythm. In addition, by remote transmission of this data, this device will permit real time telemetry and remote monitoring. This multi-utility device would therefore be of use at all levels of care including primary, secondary and tertiary care as well in both out-patient and in-patient services.

Next steps

Development of other signal processing modules and extending the hardware development work to acquire electrode data from multiple leads simultaneously.

Scholars and Project Staff

First project staff at NIT Rourkella joined on July 13, 2017. Two project staffs at IIT Kharagpur joined on Sept 04, 2017 and Jan 30, 2018, respectively.

Challenges faced

It required three round of advertisements to complete recruitment of two staffs at IIT Kharagpur. This effectively reduced the man hour that could have been provided in the project by this time to a great extent.

Financial Information

  • Total sanction: Rs. 0

  • Amount received: Rs. 0

  • Amount utilised for Equipment: Rs. 0

  • Amount utilised for Manpower: Rs. 0

  • Amount utilised for Consumables: Rs. 0

  • Amount utilised for Contingency: Rs. 0

  • Amount utilised for Travel: Rs. 0

  • Amount utilised for Other Expenses: 0

  • Amount utilised for Overheads: Rs. 0

Equipment and facilities


1 Tektronix Arbitrary Function Generator, 1 Lecroy Digital Storage Oscilloscope, 2 TI DSP Development Board, 3 Desktop Computer, 1 Laptop Computer, 1 PowerEdge Server