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Light based ultrasound array detector development for diagnosing RBC under various disease model in infant

Primary Information

Domain

Environmental Science & Climate Change

Project No.

7211

Sanction and Project Initiation

Sanction No:

Sanction Date: 00/00/0000

Project Initiation date: 04/05/2017

Project Duration: 36 months

Partner Ministry/Agency/Industry

ICMR

Principal Investigator

PI Image

Samir Kumar Biswas
Indian Institute of Technology Hyderabad

Co-PIs

CO-PI Image

Kamal P Singh
Indian Institute of Science Education and Research (IISER) Mohali

CO-PI Image

Prof. Dr. Aseem Bhatnagar
INMAS DRDO New Delhi

Host Institute

 

Scope and Objectives

Objective # 1: Design and develop sensitive ultrasound detector with light.

Objective # 2: Design and develop a custom design optical tweezer and a photoacoustic tomographic microscope for diagnosing RBC.

Objective # 3: In-vivo spectral data acquisition for intrinsic various parameters estimation for RBC .

Deliverables

Develop high frequency (>50MHz) low noise ultrasound detector with light.

A prototype photo-acoustic model system for diagnosing red blood cell direct from blood vessel in infant mouse model.

Scientific Output

Developed low frequency ultrasound detector with light.

developed a prototype micro-fluidic channel with dielectric bead inside it to mimicking blood vessels and ref blood cell in it.

Developed a photo-acoustic model system for diagnosing micron size particle. Later stage the micro-fluidic channels will be replaced with infant mouse blood vessels.

Results and outcome till date

To diagnose the RBC in the live subject, we have developed a prototype system which facilitates to hold or arrest the 8-7 micron size dielectric bead (similar to RBC) in aqueous solution. Now we are optimising the system using dielectric particle ( similar to RBC) in micro-fluidic channel to mimicking the micron size blood vessel. we have detected upto 10MHz acoustic signal in aqueous medium with open light beam and now translating it to optical fiber.

Societal benefit and impact anticipated

Final aim is to diagnose red blood cell non-invasively for infant

Next steps

Making set up for generating above 10MHz (Central frequency) and large bandwidth acoustic signal and preparing testing unit for detecting high frequency acoustic signal using optical fiber tips based acoustic sensor. This sensor will be integrated with the prototype photo acoustic system to detect high frequency acoustic signals from micron size bead and red blood cells.

Publications and reports

 

Patents

Title: Mn-Al-Fe Impregnated RGO Hybrid for Arsenic Remediation with Redox and Photo-catalytic Synergism: Sludge as Possible Super-capacitor
Inventors:Kamal Krishna Kar, Janakarajan Ramkumar, Yaswanth Kumar Penke, Amit Kumar Yadav, Iram Malik, Alekha Tyagi

Scholars and Project Staff

2 research scholars are employed.

Challenges faced

we have successfully detected 10MHz (bandwidth limited) in open light beam though we are struggling with optical fiber based optical fringe separation when the the medium is exposed with 2.2MHz and 10MHz frequency acoustic signals.

Other information

 

Financial Information

  • Total sanction: Rs. 18500000.00 lakhs

  • Amount received: Rs. 13300000.00 lakhs

  • Amount utilised for Equipment: 4500000.00 lakhs

  • Amount utilised for Manpower: Rs. 856000.00 lakhs

  • Amount utilised for Consumables: 1770000.00 lakhs

  • Amount utilised for Contingency: 1780000.00 lakhs

  • Amount utilised for Travel: Rs. 25000.00 lakhs

  • Amount utilised for Other Expenses: Rs. 18.00 lakhs

  • Amount utilised for Overheads: 1900000.00 lakhs

Equipment and facilities

 

Multi-Channel Data Acquisition system, Camera, optical components, optical table, microscopic frame.