Advanced nanotracers for product life cycle assessment and product monitoring
Primary Information
Domain
Nano-Technology Hardware
Project No.
6408
Sanction and Project Initiation
Sanction No: F.No. 3-18/2015-T.S.-I(Vol.III)
Sanction Date: -
Project Initiation date: 19/08/2017
Project Duration: 36
Partner Ministry/Agency/Industry
Government of Gujarat, Industry and Mines Department
Role of partner: GOG has provided the financial support for infrastructural development cost and consumable cost. No manpower, overhead, travel cost are covered from the GOG support.
Support from partner: They have provided the entire half of the contributing fund in one go.
Principal Investigator
Prof. Superb Misra
Indian Institute of Technology-Gandhinagar
Host Institute
Co-PIs
Prof. Alok Dhawan
Indian Institute of Toxicological Research (Lucknow)
Prof. Rishi Shanker
Institute of Life Sciences, Ahmedabad
Dr. Balasubramanian C
Institute for Plasma Research, Gandhinagar
Scope and Objectives
a) Development of prototype: Introduce the iNPs into products for biomedical and environmental applications. b) Testing: iNP embedded products would be used to study the fate of the samples when released in environmental conditions. c) Safety Assessment studies: Technology demonstration and feasibility study for biomedical product monitoring and in vitro cell culture studies showing occupational exposure studies.
Deliverables
Scientific Output
a) Developed a new method to introduce 65Cu (100% enriched isotope) into ferrite nanoparticles. b) Studies show that environmental media can circumvent the toxicological impact of certain nanomaterials. c) Performed cell culture studies to test the compatibility of the nano tracers
Results and outcome till date
a) Developed a new method to introduce 65Cu (100% enriched isotope) into ferrite nanoparticles.
b) Studies show that environmental media can circumvent the toxicological impact of certain nanomaterials.
c) Performed cell culture studies to test the compatibility of the nano tracers.
d) Successfully embedded stable isotope of silver in SS and titanium alloy implant surfaces. This was done through ion implantation and physical vapour deposition
e) Successfully doped 65Copper isotope into ferrite structure.

Societal benefit and impact anticipated
This will allow product monitoring of implants and also life cycle assessment of nano embedded products
Next steps
Publications and reports
1. S Chakraborty, A Nair, M Paliwal, A Dybowska, SK Misra. (2018) Exposure media a critical factor for controlling dissolution of CuO nanoparticles. Journal of Nanoparticle Research, 20 (12), 331.
2.Zhang, P, Misra, SK et al. (2019). Stable isotope labelling of metal/metal oxide nanomaterials for environmental and biological tracing. Nature Protocols. Accepted.
3. Chakraborty S, Misra SK. (2019) A comparative analysis of dialysis based separation methods for assessing copper oxide nanoparticle solubility. Env. Nanotechnol, Monitoring & Management. Accepted.
4. Paruthi A, Rajput V, Misra SK. (2019) Single platform spin-spin nuclear relaxation time (1H NMR) based technique for assessing dissolution and agglomeration of CuO nanoparticles. NanoImpact, 14, 100148.
5. Kansara K, Paruthi A, Misra SK, Karakoti A, Kumar A. (2019) Montmorillonite Clay and Humic Acid Modulate the Behavior of Copper Oxide Nanoparticles in Aqueous Environment and Affect Dorsoventral Axis and Neural Network in Zebrafish Embryo. Env. Poll. Accepted.
Patents
Discussions have started to patent ion implanted implant surfaces
Scholars and Project Staff
Ms. Bharti Malvi: 3 years (Research Scholar)
Mr. Param Punj Singh: 2 years (Research Scholar)
Ms. Pravalika Butreddy: MTech student
Challenges faced
Procurement of isotopes is getting time consuming and difficult as there is only one source of these isotopes
Other information
Financial Information
-
Total sanction: Rs. 15742600
-
Amount received: Rs. 12024100
-
Amount utilised for Equipment: Rs. 2500000
-
Amount utilised for Manpower: Rs. 829033
-
Amount utilised for Consumables: Rs. 4237850
-
Amount utilised for Contingency: Rs. 128161
-
Amount utilised for Travel: Rs. 207626
-
Amount utilised for Other Expenses: 130000
-
Amount utilised for Overheads: Rs. 384200
Equipment and facilities
Positive Pressure room for handling stable isotopes (including non refrigerated centrifuge, stirrer)