Scope and Objectives

a) Development of prototype: Introduce the iNPs into products for biomedical and environmental applications. b) Testing: iNP embedded products would be used to study the fate of the samples when released in environmental conditions. c) Safety Assessment studies: Technology demonstration and feasibility study for biomedical product monitoring and in vitro cell culture studies showing occupational exposure studies.

Deliverables

Scientific Output

a) Developed a new method to introduce 65Cu (100% enriched isotope) into ferrite nanoparticles. b) Studies show that environmental media can circumvent the toxicological impact of certain nanomaterials. c) Performed cell culture studies to test the compatibility of the nano tracers

Results and outcome till date

a) Developed a new method to introduce 65Cu (100% enriched isotope) into ferrite nanoparticles.
b) Studies show that environmental media can circumvent the toxicological impact of certain nanomaterials.
c) Performed cell culture studies to test the compatibility of the nano tracers.
d) Successfully embedded stable isotope of silver in SS and titanium alloy implant surfaces. This was done through ion implantation and physical vapour deposition
e) Successfully doped 65Copper isotope into ferrite structure.

Societal benefit and impact anticipated

This will allow product monitoring of implants and also life cycle assessment of nano embedded products

Next steps

Publications and reports

1. S Chakraborty, A Nair, M Paliwal, A Dybowska, SK Misra. (2018) Exposure media a critical factor for controlling dissolution of CuO nanoparticles. Journal of Nanoparticle Research, 20 (12), 331.
2.Zhang, P, Misra, SK et al. (2019). Stable isotope labelling of metal/metal oxide nanomaterials for environmental and biological tracing. Nature Protocols. Accepted.
3. Chakraborty S, Misra SK. (2019) A comparative analysis of dialysis based separation methods for assessing copper oxide nanoparticle solubility. Env. Nanotechnol, Monitoring & Management. Accepted.
4. Paruthi A, Rajput V, Misra SK. (2019) Single platform spin-spin nuclear relaxation time (1H NMR) based technique for assessing dissolution and agglomeration of CuO nanoparticles. NanoImpact, 14, 100148.
5. Kansara K, Paruthi A, Misra SK, Karakoti A, Kumar A. (2019) Montmorillonite Clay and Humic Acid Modulate the Behavior of Copper Oxide Nanoparticles in Aqueous Environment and Affect Dorsoventral Axis and Neural Network in Zebrafish Embryo. Env. Poll. Accepted.

Patents

Discussions have started to patent ion implanted implant surfaces

Scholars and Project Staff

Ms. Bharti Malvi: 3 years (Research Scholar)
Mr. Param Punj Singh: 2 years (Research Scholar)
Ms. Pravalika Butreddy: MTech student

Challenges faced

Procurement of isotopes is getting time consuming and difficult as there is only one source of these isotopes

Other information