Project Title

Instrument-free Point-of-care Device for Detection of Pathogens and Antimicrobial resistance

Project Images

Image Caption:Concentration of Bacteria on a Nanoparticle impregnated Smart Substrate for Detection of Pathogens and Antimicrobial resistance in various Infections

Web Abstract

Multidrug resistance in bacterial infections is increasing globally. The essential first step of rational antibiotic use is the diagnosis of whether the infection is of bacterial or viral origin and then identification of the bacteria. The existing methods for the distinguishing bacteria from viruses involve the use of expertise in microscopy, serology and microbiological culture. We will develop and validate a point of care device for distinguishing bacteria from viruses, and the further classification and identification of bacteria into Gram positive or negative and a preliminary antimicrobial sensitivity to common drugs. This platform will help in screening causative organisms in infections and will be inexpensive, accessible, affordable, and easy to read. This will enable triage of those cases that require antibiotic therapy and those that require further referrals. Such a system will decrease the indiscriminate use of antibiotics and address the emergence of antimicrobial resistant strains globally.