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Proposal Number: 6183

Domain: Healthcare

Theme(s): Point of care diagnostic tests and surveillance systems for common non-communicable and Infectious diseases
Trauma and Accidents Care

Supporting Central Government Agency:

Budget (Rs. Lakhs): 386.00

Principal Investigator: Dr. Ashis Kumar Sen

Principal Investigator Institute: Indian Institute of technology Madras

Co-Investigators:
Dr. Madhulika Dixit ,Indian Institute of technology Madras
Paul Ramesh Thangaraj ,Apollo Hospitals, Chennai
Muraleedharan K. M. ,Indian Institute of technology Madras
Jayashree Gopal ,Apollo Hospitals, Chennai
Anil Tarigopula ,Apollo Hospitals, Chennai
Anil Prabhakar ,Indian Institute of technology Madras
Dr. Ananth Krishnan ,Indian Institute of technology Madras

Domain: Healthcare

Project Title

Microfluidic platform for continuous monitoring of gasotransmitters for early level management of Systemic Inflammatory Response Syndrome (SIRS) in Trauma patients

Project Images

Image Caption:Schematic of the proposed microfluidic system for monitoring of gasotransmitters

Web Abstract

One-third of all in hospital patients, greater than 50% of all ICU patients and more than 80% of surgical ICU patients suffer from SIRS induced morbidity and mortality with diminishing chances of survival due to delayed diagnosis and poor prognosis. Microbial tests are time consuming and the currently available biochemical markers lack specificity and can detect only at later stages of sepsis. Thus, early diagnosis of SIRS in acute trauma patients is mandatory for effective management. In this project, we will develop a microfluidics based novel Lab on Chip (LOC) platform for continuous monitoring of vascular gasotransmitters with high selectivity, specificity and accuracy for detecting SIRS. We also intend to understand the interrelationship between gasotransmitters, for studying the endothelial function and clinical outcomes in SIRS signaling.