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Proposal Number: 5450

Domain: Advanced Materials

Theme(s): Materials for better health/health services

Supporting Central Government Agency: Indian Council of Medical Research

Budget (Rs. Lakhs): 127.01

Principal Investigator: Subha Narayan Rath

Principal Investigator Institute: Indian Institute of Technology Hyderabad

Co-Investigators:
Chandra Sekhar Sharma ,Indian Institute of Technology Hyderabad
Dr GV Rao ,Asian Institute of Gastroenterology, Hyderabad
Dr R Pradeep ,Asian Institute of Gastroenterology, Hyderabad
Dr M Sasikala ,Asian Institute of Gastroenterology, Hyderabad
Dr R Talukdar ,Asian Institute of Gastroenterology, Hyderabad
Dr D Nageshwar Reddy ,Asian Institute of Gastroenterology, Hyderabad

Domain: Advanced Materials

Project Title

Development of macro-encapsulation device for islet cell transplantation for diabetes treatment

Project Images

Image Caption:Macro-encapsulation device for cell therapy

Web Abstract

We plan to indigenously develop a macroencapsulation device for cellular therapy, especially islet transplantation in the management of uncontrolled diabetes. The basic aim is to use allogenic or xenogeneic cells in a macroencapsulation device in which, the cells secrete the required proteins without being affected by host immune cells attacking them. The porous chamber should allow the smaller protein molecules to pass out and nutrients like glucose, amino acids to pass in; but should not let the bigger immune cells to enter into the device.