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Proposal Number: 5400

Domain: Healthcare

Theme(s): Point of care diagnostic tests and surveillance systems for common non-communicable and Infectious diseases

Supporting Central Government Agency: Ministry of Health and Family Welfare

Budget (Rs. Lakhs): 228.00

Principal Investigator: SEYED E. HASNAIN

Principal Investigator Institute: Kusuma School of Biological Science, Indian Institute of Technology, Delhi

Co-Investigators:
Ravikrishnan Elangovan ,Department of Biochemical Engg and Biotechnology, Indian Institute of Technology, Delhi
NASREEN Z. EHTESHAM ,Senior Deputy Director, National Institute of Pathology, Safdarjung Hospital.
Prof Vijay K Chaudhary ,Department of Biochemistry, University of Delhi South campus, New Delhi
Professor Surendra K Sharma ,Department of Medicine , All India Institute of Medical Sciences, New Delhi
Dr Amita Gupta ,Department of Biochemistry University of Delhi South campus, New Delhi
Saurabh Singh ,CEO, Valetude Primus Healthcare Pvt Ltd

Domain: Healthcare

Project Title

Development of an affordable, automated and field deployable, point of care and contained system for rapid diagnosis of TB caused by Mycobacterium tuberculosis

Web Abstract

Tuberculosis (TB) is major global health burden causing 1.5 million deaths annually. Affordable and sensitive detection of TB is urgently required to catch 3x106 TB patient who are left undiagnosed. Definitive diagnostics of pulmonary TB is performed by confirming the presence of Mycobacterium tuberculosis (MTB) in sputum samples. Currently smear microscopy is the main diagnostic method used in India, which lacks desired sensitivity. We propose to develop a field deployable, automated, affordable and rapid MTB diagnostics test-system called “iMC2 TB test”. This involves thinning of the sputum sample in a single use capture bottle preloaded with reagents and followed by immuno-magnetic enrichment of the MTB cells using an automated, portable device. Enriched MTB cells will be confirmed using an inbuilt fluorescent detector. Assay kit will be pre-packaged, designed to drastically minimize exposure of aerosol to clinical workers, would cost around 300-500 INR and will take about 60 minutes per sample.