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Proposal Number: 7419

Domain: Healthcare

Theme(s): Trauma and Accidents Care

Supporting Central Government Agency:

Budget (Rs. Lakhs): 95.57

Principal Investigator: Dr. Santanu Dhara

Principal Investigator Institute: Indian Institute of Technology Kharagpur

Co-Investigators:
Prof. Ashok Kumar ,Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur

Domain: Healthcare

Project Title

Design and Fabrication of Composite Scaffolds for Skeletal Injuries from Biological Waste Materials

Project Images

Image Caption:Skeletal tissue healing using 3D printed Egg Shell based customized scaffold

Web Abstract

On an average day, big hospital in India treats approximately 75 fresh fractures cases, out of which at least 5–8 require operative intervention. Almost 500–700 cases of nonunions and infected nonunions are treated per year. Hence, we are dealing with an enormous burden of fresh fractures and complicated trauma. Bone graft is the second most common transplantation tissue, with blood being by far the commonest. A large number of bone-graft 
alternatives are currently commercially available for orthopaedic use. They vary in composition, mechanism of action, and special characteristics. However, they are not affordable by the common people. In this context, the proposal deals with a process where the biological waste is recycled into bone substitutes by creating a bioink, which is osteoconductive, osteoinductive, biocompatible, bio-resorbable, structurally similar to bone, easy to use, and cost-effective. The extracted CT imaging of fracture site will be used to develop customized bone grafts by direct 3D printing using the created bioink. Multi-phasic calcium phosphate (CaP)   and   collagen   will   be   isolated from biological waste and explored for the development of bone graft. Further, different   synthetic and semi-synthetic polymers will also be used in combination to improve and tailor the mechanical properties. The created customized bone grafts will be tested for both in vitro and in vivo osteogenicity, toxicity. In addition, it will be assessed for accelerated bone healing and osseo-incorporation property in fracture animal model.