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Proposal Number: 4352

Domain: Healthcare

Theme(s): Point of care diagnostic tests and surveillance systems for common non-communicable and Infectious diseases

Supporting Central Government Agency: Ministry of Health and Family Welfare

Budget (Rs. Lakhs): 169.29

Principal Investigator: Koel Chaudhury

Principal Investigator Institute: Indian Institute of Technology Kharagpur

Co-Investigators:
Pradyumna Kumar Mishra ,National Institute for Research in Environmental Health (ICMR) Bhopal
Kailash C Pandey ,National Institute for Research in Environmental Health (ICMR) Bhopal
Suresh P. Vyas ,Dr. Harisingh Gour Central University, Sagar

Domain: Healthcare

Project Title

Aberrant circulating epigenomic signatures: Development and validation of minimal-invasive biomarkers for trans-generational monitoring of air pollution associated cancers

Project Images

Image Caption:Nanobiosensors for air pollution-assoicated cancer

Web Abstract

The increasing burden of environmental associated lung cancers has gained wider scientific attention towards designing strategies for their early diagnosis. Epigenetic signatures circulate at higher levels in individuals with lung cancer and are known to reflect the vital ongoing cellular changes. The proposed study aimed to utilize these circulating epigenetic markers and develop a minimal invasive quantum dot based liquid biopsy strategy (nano-sensor) capable of early diagnosis of lung cancers. Initially, circulating epigenomic signatures will be analysed in defined air pollution pockets of 9 different Indian cities (divided into high-risk, mid-risk and low-risk settings) to identify a probable disease marker. Later, the identified optimum signature will be utilized for designing a quantum-FRET based nano-sensor technology for disease diagnosis. This liquid biopsy based approach will certainly help to develop a low cost minimal-invasive point of care test for early screening of lung cancers among people living in air pollution affected areas.